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/ Inside Pain Blog / Neuromodulation


At Pain Doctor, we conduct clinical research so that we can lead the way in developing the next generation treatments for pain. One of these frontiers in pain management is neuromodulation.

Researchers in the late 1960s discovered that they could reduce pain through neuromodulation, a technique that involves delivering electrical pulses to the nervous system, and is based on the Gate Control Theory of pain. According to this theory, when a large amount of sensory information is being sent to the brain, the nervous system naturally reduces how intense we perceive that sensation to be. In Gate Control Theory, this process is called “closing the gate.” Neuromodulation takes advantage of this gate closing process.

Treating pain through neuromodulation involves sending non-painful electrical pulses to the same nerve or nerves conveying the pain signals. Because the nerve is sending so many signals, both pain and stimulation from the mild electrical pulses, the brain “closes the gate,” and the pain feels less intense. Decades of research has demonstrated the efficacy of various approaches at neuromodulation for reducing pain in many patients.

Neuromodulation is most effective for pain that is neuropathic, meaning pain that originates in the nerves themselves. Neuropathic pain can be caused by damage to the nerves from physical trauma (e.g., a car accident) or surgery, but sometimes the cause of neuropathic pain is not known. Neuropathic pain may last for months or even years — long after damage to other bodily tissues has healed.

There are several types of devices that use neuromodulation for pain management. For example, transcutaneous electrical nerve stimulation (TENS) units send neuromodulating electrical pulses through patches attached to the skin. Other devices, such as spinal cord stimulators or peripheral nerve stimulators, are implanted under the skin so that they can more directly affect nerves.

One of our ongoing clinical trials involves testing a new neuromodulation device, the Bioness StimRouter. This is a peripheral nerve stimulator, and it’s designed to treat neuropathic pain originating in a single peripheral nerve. Peripheral nerves are sensory nerves other than those of the spine, neck and head. For example, a person may have chronic neuropathic pain in their shoulder or knee as a result of a previous surgical

procedure in that area. This device consists of a small lead (approximately 6-inches long) that is implanted under the skin in the area of the pain along with an electrical pulse transmitter (EPT) placed on the skin with an adhesive patch. The EPT is controlled by the patient wirelessly with a small remote.

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adjective uk / ˈθæl.ə.mɪk / / θəˈlæm.ɪk / / ˈθæl.ə.mɪk / / θəˈlæm.ɪk /
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There is also significant necrosis in the and cerebral cortex.
The third order neuron in the then connects to the sensory cortex of the postcentral gyrus.
The anterior cingulate cortex receives primarily its afferent axons from the intralaminar and midline thalamic nuclei (see ).
Caudally, the subthalamus or prethalamus is separated from the by the zona limitans intrathalamica.
In general, strokes damage one hemisphere of the brain, which can include the .
Damage to the can lead to permanent coma.
Due to their different ontogenetic origins, the epithalamus and the perithalamus are formally distinguished from the proper.
The , however, is tonically inhibited by the basal ganglia.
From the , touch/position and pain/temperature information is projected onto various areas of the cerebral cortex.
The two parts of the surround the third ventricle.
However, sleep spindles can only be generated by the , making its role very important.
The also plays an important role in regulating states of sleep and wakefulness.
The is known as the gateway to the cortex.
The pulvinar nuclei of the play a major role in attention, and filter out unnecessary information.
The electrodes stimulate the area of the , specifically the part of the brain that controls movement and muscle function.

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